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Dox-induced cardiac pathologic changes. Hearts were obtained 4 days after Dox (at 20 mg/kg) or saline treatment. Coronal sections of the heart were stained with H&E. A, saline-treated wild-type mice; B, saline-treated null mice; C, Dox-treated wild-type mice; D, Dox-treated null mice. The results shown are typical of four mice examined in each group. Arrows indicate sites of myocardial degeneration. Bar = 50 μm
