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. Author manuscript; available in PMC: 2008 Oct 29.
Published in final edited form as: Biometrics. 2007 Oct 25;64(2):567–576. doi: 10.1111/j.1541-0420.2007.00928.x

Table 1.

Simulation results based on 1000 Monte Carlo data sets when the true model is the PH or PO model with baseline density f0(t). Mean is Monte Carlo mean of the 1000 estimates of β when the true model is fitted, SD is their Monte Carlo standard deviation, SE is the average of the 1000 estimated delta method standard errors, and CP is Monte Carlo coverage probability, expressed as a percent, of 95% Wald confidence intervals. For right-censored data, SNP and PL indicate fitting using the SNP approach with K and the base density chosen via HQ and partial likelihood, respectively. All of the AFT, PH, and PO models were fitted to each data set under right-censoring; the columns AFT, PH, and PO indicate the percentage of 1000 data sets for which that model was chosen based on HQ, and Correct indicates the percentage of data sets supporting the PH model; see the text. For interval-censored data, only SNP was used. (a) PH model: true value of β = 2.0 in all cases. (b) PO model: true value of β = 2.0 (lognormal, Weibull) or β = −2.0 (log-mixture).

f0(t) n Cens. rate Method Mean SD SE CP AFT PH PO Correct
(a) True PH model
Right-censored data
lognormal 200 25% SNP 2.02 0.32 0.31 95.4 9.4 86.5 5.2 86.5
PL 2.00 0.32 0.32 96.3
Weibull 200 25% SNP 2.02 0.31 0.31 95.5 86.7 88.0 2.8 97.2
PL 2.01 0.32 0.32 96.3
gamma 200 25% SNP 2.06 0.32 0.31 94.3 66.8 81.6 6.3 81.6
PL 2.02 0.32 0.32 95.2
log-mixture 200 25% SNP 2.04 0.34 0.33 94.9 2.4 73.6 24.0 73.6
PL 2.02 0.33 0.33 95.5
Interval-censored data
gamma 200 18% right, 82% interval SNP 2.04 0.30 0.29 93.9
log-mixture 200 20% right, 80% interval SNP 2.04 0.30 0.30 94.8
(b) True PO model
Right-censored data
lognormal 200 25% SNP 2.01 0.18 0.18 94.6 0.7 2.2 97.1 97.1
Weibull 200 25% SNP 2.00 0.46 0.45 94.6 29.4 19.7 65.1 65.1
log-mixture 200 25% SNP −1.99 0.46 0.45 95.3 1.4 15.4 83.2 83.2
Interval-censored data
log-mixture 200 20% right, 80% interval SNP −2.01 0.48 0.47 95.7