Table 2.
Baseline data in the three group rabbits
| Vehicle | Simvastatin | Simvastatin + L-NAME | ||||
|---|---|---|---|---|---|---|
| n | 6 | 7 | 5 | |||
| Before | After | Before | After | Before | After | |
| BW, kg | - | 3.9 ± 0.4 | - | 3.6 ± 0.3 | - | 4.1 ± 0.3 |
| HW/BW, g/kg | - | 3.4 ± 0.3 | - | 3.5 ± 0.5 | - | 3.2 ± 0.3 |
| LW/BW, g/kg | - | 5.4 ± 0.3 | - | 5.1 ± 0.4 | - | 4.9 ± 0.5 |
| MAP, mm Hg | 70.6 ± 3.4 | 73.2 ± 5.9 | 73.7 ± 5.5 | 74.5 ± 4.2 | 72.7 ± 6.1 | 74.1 ± 4.6 |
| HR, bpm | 227.9 ± 7.5 | 241.3 ± 10.2 | 246.2 ± 6.9 | 232.9 ± 11.8 | 231.7 ± 9.4 | 239.5 ± 8.4 |
| LVEDP, mm Hg | - | 15.4 ± 2.2 | - | 14.4 ± 2.5 | - | 14.9 ± 2.6 |
| LVEDD, mm | - | 18.8 ± 0.9 | - | 17.6 ± 0.7 | - | 17.9 ± 0.8 |
| EF, % | 36.3 ± 4.1 | 34.6 ± 5.3 | 37.8 ± 5.4 | 39.2 ± 4.1 | 36.6 ± 5.3 | 37.6 ± 4.3 |
Values are means ± SE. Before: before treatment; After: at day 7 after treatment; n, no. of animals; BW, body weight; HW, heart weight; LW, lung weight; MAP, mean arterial pressure; HR, heart rate; LVEDD, left ventricular end-diastolic diameter; LVEDP, left ventricular end-diastolic pressure; EF, ejection fraction.