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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Chem Biol Drug Des. 2008 Jul 9;72(2):120–126. doi: 10.1111/j.1747-0285.2008.00682.x

Table 1.

Optimization of chiral phosphonyl auxiliary.a

graphic file with name nihms-62327-t0002.jpg
entry imine R yield (%)b drc
1 1b 1-nathphyl 81 82:18
2 2 Ph 82 77:23
3 3 2-MeO-Ph 80 72:28
4 4 iPr 60 76:24
a

Reaction condition: 0.1 mmol imine, 0.2 mmol ester, 0.22 mmol base, 2 equiv TiCl(OiPr)3, 2 mL solvent.

b

Isolated yield.

c

Determined by 31P NMR.