Table 5.

Hazard ratios for the association between two GABRA2 single nucleotide polymorphisms and age at first symptom of DSM-IIIR alcohol dependence.

Hazard Model		Single Nucleotide Polymorphism
		rs279858	rs279845	rs279845 recessive
Model 1
	genotype (0/1/2)	1.1 [1.02−1.19]	1.1 [1.01−1.19]
Model 2
	sex	0.48 [0.43−0.53]	0.47 [0.42−0.53]
	genotype (0/1/2)	1.09 [1.01−1.18]	1.08 [1.00−1.16]
Model 3
	sex	0.44 [0.36−0.55]	0.40 [0.32−0.49]
	genotype (0/1/2)	1.06 [0.96−1.18]ns	1.01 [0.92−1.12]ns
	sex* genotype (0/1/2)	1.06 [0.91−1.22]ns	1.14 [0.98−1.34]ns
Model 4
	genotype (0/1)	1.18 [1.03−1.36]	1.14 [0.98−1.34]ns	1.13 [1.01−1.27]
Model 5
	sex	0.47 [0.42−0.53]	0.47 [0.42−0.52]	0.47 [0.42−0.52]
	genotype (0/1)	1.19 [1.03−1.37]	1.13 [0.98−1.30]ns	1.09 [0.97−1.22]ns
Model 6
	sex	0.46 [0.35−0.59]	0.43 [0.33−0.55]	0.43 [0.38−0.50]
	genotype (0/1)	1.17 [0.96−1.42]ns	1.07 [0.89−1.30]ns	0.98 [0.84−1.15]ns
	sex* genotype (0/1)	1.04 [0.78−1.39]ns	1.12 [0.84−1.49]ns	1.26 [1.0−1.58]

ns = non significant (p > 0.05)