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. Author manuscript; available in PMC: 2008 Oct 29.
Published in final edited form as: Science. 2008 May 15;320(5882):1507–1510. doi: 10.1126/science.1159051

Fig. 2.

Fig. 2

Activation of DDR depends on ATM and DNAPK. (A) Detection of γH2AX by indirect immunofluorescence in NIH 2/4 cells transiently transfected for 24h with lacR-NBS1- CherryRed (red) and treated with the indicated kinase inhibitor for 24h. γH2AX (green). Scale Bar = 2µm. (B) Quantitative analysis of H2AX phosphorylation on the lacO array after immobilization of the indicated repair factors in the presence of signaling inhibitors. Values represent averages ± S.D (n = 50) from 4 independent experiments.