Figure (3).

Inactivation of both late scattered mode (A) or burst mode (B) of the late openings of Na⁺ channel was slowest in failing human cardiomyocytes compared with those from normal human hearts or heterologously expressed Na_v1.5. *P<0.05, heart failure vs. normal heart or clone (Mean±SEM). Cell-attached patches, 24°C. (Adapted from [12]). C: recordings of action potentials in failing human cardiomyocytes are shown along with the late scattered mode and burst mode openings occurring at -10 mV, i.e. within the voltages of the action potential plateau. Adapted from [12, 40], used with permission.