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A: Frequency-dependence of action potential duration in ventricular cardiomyocytes of normal dogs and dogs with chronic heart failure. Note that largest difference occurs at low pacing rates. B: at the low (0.2 Hz) and the physiologic (1 Hz) pacing rates, AP duration in failing myocytes exhibits significant beat-to beat variability (see respective SD values in the APD90 distribution histograms) Adapted from [10] with permission.
