Table 2.
Rectal temperatures during experimental focal cerebral ischemia and plasma estradiol levels in ERαWT and ERαKO mice and ERβWT and ERβKO mice
| Group | Rectal temperatures (°C)
|
Estradiol (pg/mL) | |||
|---|---|---|---|---|---|
| Preischemia | Ischemia
|
Reperfusion | |||
| 5 mins | 115 mins | 5 mins | |||
| Sham PC ERαWT (n = 9) | 36.7 ± 0.1 | 37.1 ± 0.2a,d | 36.7 ± 0.2a | 37.0 ± 0.2a | 17 ± 2 (n = 8) |
| IsoPC ERαWT (n = 10) | 36.8 ± 0.2 | 37.4 ± 0.1a,b | 37.0 ± 0.2a | 37.3 ± 0.1a,b | 37 ± 9e (n = 8) |
| Sham PC ERαKO (n = 11) | 36.6 ± 0.1 | 37.1 ± 0.1a,b | 36.6 ± 0.1a | 37.0 ± 0.1a,b | 31 ± 3 (n = 10) |
| IsoPC ERαKO (n = 10) | 36.5 ± 0.1 | 37.1 ± 0.1a,b | 36.7 ± 0.1a | 37.1 ± 0.1a,b | 27 ± 4 |
| Sham PC ERβWT (n = 9) | 36.5 ± 0.1 | 36.5 ± 0.1 | 36.3 ± 0.2 | 36.4 ± 0.1 | 25 ± 2 |
| IsoPC ERβWT (n = 9) | 36.6 ± 0.1c | 36.6 ± 0.1c | 36.1 ± 0.2 | 36.3 ± 0.1 | 23 ± 2 (n = 7) |
| Sham PC ERβKO (n = 10) | 36.5 ± 0.1 | 36.6 ± 0.1 | 36.2 ± 0.2 | 36.4 ± 0.1 | 32 ± 2 |
| IsoPC ERβKO (n = 13) | 36.4 ± 0.1 | 36.5 ± 0.1 | 36.1 ± 0.2 | 36.3 ± 0.1 | 26 ± 2 |
ERαKO, estrogen receptor-alpha knockout; ERβKO, estrogen receptor-beta knockout; ERαWT, estrogen receptor-alpha wild-type; ERβWT, estrogen receptor-beta wild-type; IsoPC, isoflurane preconditioning; sham PC, sham preconditioning.
a
P < 0.05 as compared with ERβ groups.
b
P < 0.05 as compared with preischemia and 115 mins of ischemia within the treatment group.
c
P < 0.05 as compared with 115 mins of ischemia within the treatment group.
d
P < 0.05 compared with preischemia within the treatment group.
e
P < 0.05 as compared with sham PC.