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. Author manuscript; available in PMC: 2009 Sep 1.
Published in final edited form as: Lab Invest. 2008 Sep 8;88(11):1178–1191. doi: 10.1038/labinvest.2008.83

Figure 7.

Figure 7

Effect of anti-ricin monoclonal immunoglobulin administered after ricin challenge. At designated time intervals after injection of ricin (40 μg/kg), C57BL/6 mice were administered 20 μg each of RAC 17, 18, and 23 i.v., or the same quantity of isotype-matched monoclonal immunoglobulin; assessed every 24 hours for blood glucose,; and monitored for survival. A. Blood glucose of surviving mice by treatment group (N=10/group). One group did not receive ricin (non-ricin ctl) and one group was administered ricin then irrelevant immunoglobulin (ctl IgG). B. Survival shown as the percentage of mice alive in each treatment group (N=10/group). Note that 100 % of mice receiving irrelevant immunoglobulin succumbed by day 4, while 30% of mice administered specific immunoglobulin 14 hours after ricin exposure survived. Survival curves overlap for mice receiving anti-ricin antibody 8 and 10 hours after ricin challenge.