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wt and R3 viruses show similar sensitivities for conformational antibodies. Single cycle infection experiments in TZM-bl cells containing a luciferase reporter construct under control of the HIV-1 LTR were carried out in the presence of escalating concentrations of CD4-IgG2 (A) and monoclonal antibodies b12 (B) and 2G12 (C). The luciferase activity in the absence of inhibiting reagents was set at 100%.
