Figure 1. The gene encoding human serum- and glucocorticoid-regulated kinase 1 (SGK) on chromosome 6q23.

A) Exons (light grey) and untranslated regions (dark grey) are indicated. Four tagging SNPs were selected by HapMap analysis considering the SGK gene ±10 kb upstream of the first translational start codon and 1.5 kb downstream of the 3′ untranslated region. SNP information is provided in boxes (var = variation; MAF = minor allele frequency; HWE = Hardy-Weinberg equilibrium, χ² test) for populations investigated for all tagging SNPs (South German TUEF cohort/Finnish METSIM cohort). B) Linkage disequilibrium analysis of selected tagging SNPs for the TUEF and METSIM population: D' (in bold, upper numeral) and r² (bottom numeral).