Table 2. Metabolic Traits of the German Cohort according to rs9402571 genotype.
| SNP Genotype | ______rs9402571______ | p1 | p2 | ||
| TT | TG | GG | |||
| N | 434 | 251 | 40 | - | - |
| Age (y) | 37.0±0.6 | 37.1±0.8 | 39.6±2.2 | 0.44 | 0.62 |
| BMI (kg/m2) | 29.0±0.4 | 30.0±0.6 | 28.9±1.3 | 0.24a | 0.20 |
| Fasting glucose (mM) | 5.10±0.03 | 5.05±0.04 | 5.08±0.09 | 0.10b | 0.0376 |
| Glucose, 120 min OGTT (mM) | 6.19±0.08 | 6.11±0.11 | 6.33±0.29 | 0.31b | 0.16 |
| Insulin sensitivity, OGTT (U) | 17.1±0.5 | 16.9±0.8 | 14.1±1.4 | 0.12b | 0.64 |
| C-Peptide, 30 min OGTT (pM) | 2020±43 | 2153±60 | 2239±158 | 0.12c | 0.0398 |
| AUCC-peptide/AUCglucose, OGTT (·10−9) | 318±5 | 335±7 | 342±18 | 0.09b | 0.0416 |
Data are given as means±SEM; p1–additive model; p2–dominant model. AUC–area under the curve; OGTT–oral glucose tolerance test; SNP–single nucleotide polymorphism.
a
adjusted for age and gender.
b
adjusted for age, gender and BMI.
c
adjusted for age, gender, BMI and insulin sensitivity.