Table 5.

Recommended Classification of Incidental Findings

Category	Relevant IFs	Recommended Action
Strong Net Benefit	information revealing a condition likely to be life-threatening information revealing a condition likely to be grave that can be avoided or ameliorated genetic information revealing significant risk of a condition likely to be life-threatening genetic information that can be used to avoid or ameliorate a condition likely to be grave genetic information that can be used in reproductive decision-making: (1) to avoid significant risk for offspring of a condition likely to be life-threatening or grave or (2) to ameliorate a condition likely to be life-threatening or grave	Disclose to research participant as an incidental finding, unless s/he elected not to know.
Possible Net Benefit	information revealing a nonfatal condition that is likely to be grave or serious but that cannot be avoided or ameliorated, when a research participant is likely to deem that information important genetic information revealing significant risk of a condition likely to be grave or serious, when that risk cannot be modified but a research participant is likely to deem that information important genetic information that is likely to be deemed important by a research participant and can be used in reproductive decision-making: (1) to avoid significant risk for offspring of a condition likely to be serious or (2) to ameliorate a condition likely to be serious	May disclose to research participant as an incidental findings, unless s/he elected not to know.
Unlikely Net Benefit	information revealing a condition that is not likely to be of serious health or reproductive importance information whose likely health or reproductive importance cannot be ascertained	Do not disclose to research participant as an incidental finding.