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. 2008 Aug 7;105(33):11998–12003. doi: 10.1073/pnas.0802175105

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© 2008 by The National Academy of Sciences of the USA

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Fig. 4. — Effects of a ryanodine receptor blocker TMB-8 on the presynaptic Ca²⁺ transients elicited by the tetanic stimulation. (A) Presynaptic Ca²⁺ transients evoked by the tetanus (100 Hz 100 times) were suppressed by 10 μM TMB-8 while the initial phases were almost unaffected. Graphs represent the time course of amplitudes of Ca²⁺ transients to the 100th stimuli (ΔF₁₀₀) and F. (B) Effects of TMB-8 on the field EPSPs recorded simultaneously. Graph represents the time course of the 100th EPSP (EPSP₁₀₀).