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siRNA-mediated cleavage of PCSK9 mRNA in rats (5′-RACE). Rats (n = 4 per group) were administered with 4 mg/kg LNP-PCS-A2, LNP-Crtl, or PBS and killed 4 days later. 5′-RACE detects the predicted mRNA cleavage product in LNP-PCS-A2- and not in LNP-Crtl- or PBS-treated animals. Eighty-seven percent of clones from the circled bands mapped to the predicted siRNA specific cleavage site.
