Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2008 Jul 30;28(31):7919–7928. doi: 10.1523/JNEUROSCI.0784-08.2008

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2008 Society for Neuroscience 0270-6474/08/287919-10$15.00/0

PMC Copyright notice

Figure 7. — IP₃Rs and RyRs contribute to CICR in glycinergic amacrine cells. A, Feedback IPSC before and after bath application of thapsigargin (1 μm). B, Summarized effects (mean ± SD) of thapsigargin (1 μm), RR (40 μm), 2-APB (50 μm), and xestospongin C (XeC; 3 μm) on IPSCs. ND, Experiment not done. C, IPSCs recorded under control conditions, in the presence of Cd²⁺ and the additional presence of RR. D, IPSCs recorded under control conditions, in the presence of CPP and the additional presence of the RR. E, F, As in C and D, but with the IP₃R antagonist 2-APB. G, H, Summarized data (mean ± SD) showing that IP₃Rs and RyRs amplify specifically NMDAR-mediated and Ca_v channel-mediated Ca²⁺ signals, respectively. All experiments were performed in the presence of GABAR antagonists (SR95531 and TPMPA).