Table 1.

Inhibition of porcine erythrocyte μ–calpain and human liver cathepsin B by compounds 2 and 3.

Compound	μ-Calpain aKi (µM)	Cathepsin B Ki (µM)	bSR
2	1.94 ± 0.81	0.88 ± 0.01	0.45
3	0.08 ± 0.01	2.91 ± 0.62	36.37
cALLN	0.19 ± 0.02	0.15 ± 0.01	0.79

^aK_i values are means of triplicate determinations obtained by Dixon plots with correlation coefficient of ≥ 0.95.

^bSR is selectivity ratio, which was determined by dividing the K_i value for cathepsin B inhibition by that for calpain inhibition.

^cALLN was purchased from Calbiochem.