. Author manuscript; available in PMC: 2008 Oct 29.

Published in final edited form as: J Am Coll Cardiol. 2008 Jul 1;52(1):60–68. doi: 10.1016/j.jacc.2008.02.077

Table 2.

Neurohumoral Response to Infusion of CD-NP in Normal Dogs

	Baseline	CD-NP 10	CD-NP 50	CD-NP 100	Recovery
PcGMP (pmol/ml)	9.4 ± 1.2	14.6 ± 1.6	30.3 ± 2.1^*	50.1 ± 2.1^*	32.7 ± 6.7^*
UcGMPV (pmol/min)	1,648 ± 151	2,133 ± 234	4,566 ± 621^*	9,999 ± 1,590^*	6,661 ± 734^*
PRA (ng/ml/hr)	8.2 ± 0.8	5.3 ± 1.1^*	3.9 ± 0.7^*	6.3 ± 1.1	9.0 ± 1.8

Data are expressed as means ± SE.

p < 0.05 versus baseline.

CD-NP 10 = infusion of 10 ng/kg/min of CD-NP; CD-NP 50 = infusion of 50 ng/kg/min of CD-NP; CD-NP 100 = infusion of 100 ng/kg/min (n = 8 except n = 6 for high dose); PcGMP = plasma cyclic 3′5′ guanosine monophosphate; PRA = plasma renin activity; UcGMPV = urinary cyclic 3′5′ guanosine monophosphate excretion.