Table 1.

Summary of overlapping literature-curated genetic interactions in S. pombe and S. cerevisiae

Genetic interaction type	Interaction source		Overlapping interactions
	Detectable S. cerevisiae	Detectable S. pombe	Observed no. (%)	Average no. expected ± SD (%)	P
Synthetic lethal + synthetic sick	10,737	273	62 (23)	1.3 ± 1.3 (0.5)	<0.0001
Synthetic lethal	7,249	185	33 (18)	0.7 ± 0.9 (0.4)	<0.0001
Synthetic sick	4,152	61	10 (16)	0.2 ± 0.4 (0.3)	<0.0001
Phenotypic enhancement	1,347	170	18 (11)	0.4 ± 0.6 (0.2)	<0.0001
Phenotypic suppression	559	123	9 (7)	0.1 ± 0.4 (0.1)	<0.0001
All interactions	12,643	566	89 (16)	3.5 ± 2.3 (0.9)	<0.0001

Only detectable genetic interactions involving two genes with an ortholog in both species are considered; thus, the S. cerevisiae dataset shown here is smaller than the full ScBioGRID set, and the S. pombe dataset is smaller than the full SpGI-Overlap dataset (see Table S1). The percent observed overlapping values are always calculated with respect to the number of detectable S. pombe interactions.