Table 2.

Comparison of the SpSGA HC dataset with experimentally derived and literature-curated data for S. pombe and S. cerevisiae

Experimentally derived dataset	No. of interactions	Comparison dataset	No. of interactions	No. of detectable overlapping interactions	Observed no. of overlapping interactions (%)	Expected no. of overlapping interactions ± SD (%)	P
SpSGA HC	669	SpGI-Overlap	341	11	10 (91)	0.3 ± 0.6 (3)	<0.0001
		ScBioGRID	14,566	559	72 (14)	4.8 ± 3 (0.9)	<0.0001
		ScSGA HC	742	240	54 (23)	6 ± 3.2 (2.5)	<0.0001

The SpSGA HC dataset, containing 669 interactions, is compared to SpGI-Overlap, ScBioGRID, and ScSGA HC-derived datasets. For SpGI-Overlap and ScBioGRID, the number of interactions reported here (341 and 14,566, respectively) are the nonredundant set of SL and SS interactions that are common to SpIOB and SpBIOGRID, with no differentiation between SL and SS interactions. The number of detectable overlapping interactions is the total number of known genetic interactions in these datasets where both genes were also examined in SpSGA. The small number of detectable overlapping interactions (11) relative to the full set of SL/SS interactions in the SpGI-Overlap dataset reflects the fact that most interactions examined here by SpSGA have not previously been studied. SD = standard deviation.