Fig. 2.

Dose dependence of LTE₄-induced ear edema in WT and Cysltr1/Cysltr2^−/− mice. WT (A) and Cysltr1/Cysltr2^−/− (B) mice received intradermal injections of LTE₄ in the right ear and vehicle in the left ear (four mice per group). Ear thickness was measured with calipers at the indicated times after the injection. Results are expressed as the mean ± SE of the differences between the thickness of the right and left ears at each time point and are combined from two independent experiments. Some error bars are too small to be visible as compared to the physical size of the symbol. *, P < 0.01 vs. WT mice is presented in the plot for 30, 60, and 240 min.