Fig. 1.

Time relationship of rebound sequences to the MRCA. (Left) Results from phylogenetic trees (Fig. S2) containing the clonal sequences from pretreatment (pre) and from late time point after treatment stop (post). For each patient, the MRCA was inferred, and sampling times of the clones with the highest and lowest MRCA distance are indicated. (Right) Analysis of trees obtained from nine patients who were sampled intensively (Fig. S3) including also the clonal sequences obtained during the structured treatment interruptions (STI) and frequently thereafter. (Two identical clones from different time points had the highest distance to the MRCA in patient 106.)