Fig. 3.

Adult, but not young, PFC recurrent synapses exhibit a higher proportion of NR2B subunits compared to V1. (A and B) the NR2B antagonist ifenprodil (3 μM, bath application) is more effective at blocking the NMDA current in PFC than in V1. (C) EPSCs traces scaled by the peak amplitude, from control and ifenprodil, exhibited significantly reduced decays in both PFC and V1. However, the scaled ifenprodil-EPSCs showed very similar dynamics (inset). (D) summary graph showing a significant decrease of ifenprodil-sensitive currents of NMDA channels in adult V1 cortex (n = 6) but not in PFC (n = 8) synapses. (E) NMDA/AMPA ratios and the decay time constants of NMDA currents are not significantly different in the young rat PFC and V1 (P > 0.05).