Table 1.
Genes involved in intestinal ion transport and its regulation
| Probe set ID | Gene | Gene name/aliases | Locus link | SW over FVB, control* | SW over FVB, 4 dpi | SW over FVB, 9 dpi | Main functions |
| Transporters | |||||||
| 1425382_a_at 1434449_at 1447745_at |
aquaporin 4 | Aqp4, mMIWC | 11829 | -1.88 | 1.15 | Water transport | |
| 1417828_at | aquaporin 8 | Aqp8 | 11833 | 3.14† | Water transport | ||
| 1449475_at | ATPase, H+/K+transporting, nongastric, alpha polypeptide | cHKA, Atp12a | 192113 | 1.68 | Potassium and proton ion transport | ||
| 1422009_at 1435148_at |
ATPase, Na + /K + transporting, beta 2 polypeptide | Atp1b2, Amog | 11932 | -2.99† | -2.56 | Potassium and sodium ion transport | |
| 1435945_a_at | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 | Kcnn4, SK4, IK1 | 16534 | -0.93† | Potassium ion transport | ||
| 1425088_at | sodium channel, nonvoltage-gated, type I, alpha | mENaC, Scnn1a | 20276 | 0.9 | Sodium ion transport | ||
| 1417623_at 1448780_at |
solute carrier family 12, member 2 | Nkcc1, Slc12a2 | 20496 | -0.96† | Sodium:potassium: chloride cotransport | ||
| 1417600_at | solute carrier family 15 (H + /peptide transporter), member 2 | Slc15a2, Pept2 | 57738 | -5.28‡ | -3.69§ | -5.53‡ | Oligopeptide and proton transport |
| 1419343_at | solute carrier family 15 (oligopeptide transporter), member 1 | Slc15a1, Pept1 | 56643 | 0.59 | 3.79† | Oligopeptide and proton transport | |
| 1429467_s_at 1421445_at 1427547_a_at |
solute carrier family 26, member 3 | Slc26a3, Dra | 13487 | 6.04§ | Anion exchanger activity, transport | ||
| 1425606_at | solute carrier family 5 (iodide transporter), member 8 | Ait, Slc5a8 | 216225 | 1.79† | Ion transport | ||
| 1437259_at | solute carrier family 9 (sodium/hydrogen exchanger), member 2 | NHE2, Slc9a2 | 226999 | 2.12§ | Sodium transport | ||
| 1441236_at | solute carrier family 9 (sodium/hydrogen exchanger), member 3 | NHE3, Slc9a3 | 105243 | 0.84 | Sodium transport | ||
| Regulators | |||||||
| 1434430_s_at 1434431_x_at 1450214_at |
adenosine A2b receptor | Adora2b | 11541 | -1.72¶ | -2.89§ | -1.89† | G-protein coupled receptor protein signaling pathway |
| 1431130_at | calcineurin B homologous protein 2 (2010110P09Rik) | Chp2, Cbhp2 | 70261 | 2.38§ | Sodium ion transport; regulation of pH | ||
| 1455869_at | calcium/calmodulin-dependent protein kinase II, beta | Camk2b | 12323 | -0.85 | -3.39 | -2.46 | G1/S transition; calcium transport and signaling |
| 1416193_at | carbonic anhydrase 1 | Car1, CA I | 12346 | 3.4† | One-carbon compound metabolism, maintenance of pH | ||
| 1448949_at 1418094_s_at |
carbonic anhydrase 4 | Car4, CA IV | 12351 | 5.32† | One-carbon compound metabolism, maintenance of pH, anion transport | ||
| 1422134_at | FBJ osteosarcoma oncogene B | Fosb | 14282 | -2.54† | -1.75 | Regulation of transcription | |
| 1435162_at | protein kinase, cGMP-dependent, type II | Prkg2 | 19092 | -1.69† | Signal transduction | ||
| 1438115_a_at 1438116_x_at 1450982_at |
solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1 | NHERF1, EBP50, Slc9a3r1 | 26941 | 1.1† | Regulation of sodium: hydrogen exchange | ||
| 1451602_at | sorting nexin 6 | Snx6, TFAF2 | 72183 | -3.98‡ | -4.01 | -4.95§ | Protein and ion transport |
*The numbers represent log2 ratios resulting from individual groups comparison. Significance by t-test was: †p < 0.05; §p ≤ 0.005; ¶p ≤ 0.0005; ‡p ≤ 0.00005. Genes whose expression was confirmed by qRT-PCR are in bold.