Table 3.
IRS2 SNP and haplotype associations with breast cancer
| Matching adjusteda | Multivariate adjustedb | ||||||||
| SNP | Alleles | Cases | Controls | OR | (95% CI) | P valuec | OR | (95% CI) | P valuec |
| IRS2 | rs9515118 | ||||||||
| G/G | 386 | 404 | 1.00 | (-) | 1.00 | (-) | |||
| G/C | 201 | 201 | 1.06 | (0.83–1.34) | 1.07 | (0.83–1.37) | |||
| C/C | 28 | 23 | 1.28 | (0.72–2.29) | 0.43 | 1.28 | (0.70–2.31) | 0.40 | |
| G/C or C/C | 229 | 224 | 1.08 | (0.85–1.36) | 0.54 | 1.09 | (0.86–1.38) | 0.49 | |
| rs4773082 | |||||||||
| T/T | 157 | 205 | 1.00 | (-) | 1.00 | (-) | |||
| T/C | 327 | 299 | 1.43 | (1.10–1.86) | 1.46 | (1.12–1.91) | |||
| C/C | 156 | 146 | 1.40 | (1.03–1.91) | 0.024 | 1.31 | (0.96–1.80) | 0.07 | |
| T/C or C/C | 483 | 445 | 1.42 | (1.11–1.82) | 0.005 | 1.41 | (1.10–1.81) | 0.007 | |
| rs2289046 | |||||||||
| A/A | 275 | 248 | 1.00 | (-) | 1.00 | (-) | |||
| A/G | 245 | 284 | 0.78 | (0.61–0.99) | 0.79 | (0.61–1.01) | |||
| G/G | 32 | 57 | 0.51 | (0.32–0.81) | 0.0018 | 0.52 | (0.32–0.84) | 0.004 | |
| A/G or G/G | 277 | 341 | 0.73 | (0.58–0.92) | 0.009 | 0.74 | (0.58–0.94) | 0.016 | |
| rs754204 | |||||||||
| C/C | 155 | 198 | 1.00 | (-) | 1.00 | (-) | |||
| C/T | 328 | 315 | 1.33 | (1.02–1.73) | 1.32 | (1.01–1.73) | |||
| T/T | 159 | 142 | 1.43 | (1.05–1.94) | 0.022 | 1.32 | (0.96–1.82) | 0.07 | |
| C/T or T/T | 487 | 457 | 1.36 | (1.06–1.74) | 0.015 | 1.32 | (1.03–1.70) | 0.03 | |
| rs7987237 | |||||||||
| C/C | 470 | 491 | 1.00 | (-) | 1.00 | (-) | |||
| C/T | 156 | 149 | 1.10 | (0.85–1.43) | 1.17 | (0.90–1.53) | |||
| T/T | 15 | 11 | 1.50 | (0.68–3.31) | 0.27 | 1.56 | (0.70–3.50) | 0.13 | |
| C/T or T/T | 171 | 160 | 1.13 | (0.88–1.45) | 0.35 | 1.20 | (0.93–1.55) | 0.17 | |
| rs12584136 | |||||||||
| C/C | 579 | 588 | 1.00 | (-) | 1.00 | (-) | |||
| C/A | 54 | 56 | 0.98 | (0.66–1.44) | 0.96 | (0.64–1.43) | |||
| A/A | 4 | 3 | 1.31 | (0.29–5.88) | 0.96 | 1.44 | (0.31–6.71) | 0.98 | |
| C/A or A/A | 58 | 59 | 0.99 | (0.68–1.45) | 0.97 | 0.98 | (0.67–1.45) | 0.93 | |
| rs9559648 | |||||||||
| C/C | 269 | 306 | 1.00 | (-) | 1.00 | (-) | |||
| C/T | 304 | 268 | 1.29 | (1.02–1.62) | 1.30 | (1.03–1.65) | |||
| T/T | 66 | 73 | 1.02 | (0.71–1.49) | 0.27 | 0.97 | (0.66–1.42) | 0.34 | |
| C/T or T/T | 370 | 341 | 1.23 | (0.99–1.53) | 0.07 | 1.23 | (0.98–1.54) | 0.07 | |
| rs9559654 | |||||||||
| G/G | 301 | 317 | 1.00 | (-) | 1.00 | (-) | |||
| G/A | 248 | 250 | 1.05 | (0.83–1.33) | 1.05 | (0.82–1.34) | |||
| A/A | 67 | 59 | 1.19 | (0.81–1.75) | 0.39 | 1.19 | (0.80–1.76) | 0.40 | |
| G/A or A/A | 315 | 309 | 1.07 | (0.86–1.34) | 0.52 | 1.08 | (0.86–1.35) | 0.52 | |
| rs7997595 | |||||||||
| C/C | 434 | 453 | 1.00 | (-) | 1.00 | (-) | |||
| C/G | 161 | 170 | 0.99 | (0.77–1.28) | 1.02 | (0.79–1.32) | |||
| G/G | 19 | 9 | 2.24 | (1.00–5.01) | 0.34 | 2.31 | (1.02–5.24) | 0.23 | |
| C/G or G/G | 180 | 179 | 1.05 | (0.82–1.35) | 0.68 | 1.09 | (0.84–1.40) | 0.50 | |
| rs7981705 | |||||||||
| C/C | 435 | 470 | 1.00 | (-) | 1.00 | (-) | |||
| C/T | 190 | 164 | 1.25 | (0.98–1.60) | 1.17 | (0.91–1.51) | |||
| T/T | 17 | 19 | 0.99 | (0.50–1.93) | 0.16 | 0.90 | (0.45–1.79) | 0.43 | |
| C/T or T/T | 207 | 183 | 1.23 | (0.97–1.56) | 0.09 | 1.14 | (0.89–1.46) | 0.29 | |
| rs4773092 | |||||||||
| G/G | 152 | 170 | 1.00 | (-) | 1.00 | (-) | |||
| G/A | 333 | 303 | 1.24 | (0.95–1.62) | 1.21 | (0.92–1.60) | |||
| A/A | 132 | 118 | 1.28 | (0.92–1.78) | 0.12 | 1.30 | (0.93–1.82) | 0.11 | |
| G/A or A/A | 465 | 421 | 1.25 | (0.97–1.62) | 0.08 | 1.24 | (0.95–1.61) | 0.11 | |
| Haplotypes of rs4773082, rs2289046, and rs754204 | CAT | 296.8 | 273.2 | 1.00 | - | 1.00 | - | ||
| TGC | 188.8 | 227.4 | 0.74 | (0.62–0.90) | 0.0018 | 0.76 | (0.63–0.92) | 0.0050 | |
| TAC | 107.3 | 104.6 | 0.99 | (0.78–1.24) | 0.89 | 1.04 | (0.82–1.32) | 0.75 | |
| Other groups | 52.2 | 49.9 | 0.98 | (0.72–1.33) | 0.88 | 0.96 | (0.70–1.32) | 0.80 | |
| Global P value = 0.015 | Global P value = 0.030 | ||||||||
aAdjusted for race, birth date, and blood draw date. bAdjusted for race, birth date, blood draw date, adult weight change, breast cysts, family history of breast cancer, and hormone replacement therapy use. cFor IRS2 P values are provided for the log-additive model, and the dominant model; for Haplotypes of rs4773082, rs2289046, and rs754204, haplotype P values are compared with the most common haplotype. CI, confidence interval; IRS2, insulin receptor substrate 2 gene; OR, odds ratio.