Table 2.

Mean percentage of mammographic density (MD) according to breast cancer susceptibility loci, Nurses' Health Study controls (1989 to 1998)

		N	Mean %MDa	Mean %MDb
rs2981582	G/G	421	26.9	26.7
	G/A	539	26.9	26.6
	A/A	160	26.8	28.0
p value d			0.56	0.98
rs12443621	A/A	298	25.0	25.7
	A/G	561	27.3	26.9
	G/G	267	27.4	27.1
p value d			0.12	0.25
rs13281615	A/A	377	27.6	27.2
	A/G	553	25.9	26.3
	G/G	198	28.1	27.5
p value d			0.90	0.91
rs3817198	A/A	489	26.0	25.9
	A/G	491	27.8	27.8
	G/G	119	25.9	26.1
p value d			0.95	0.79
rs889312	T/T	622	28.3	28.2
	T/G	428	24.7	25.1
	G/G	76	28.6	27.3
p value d			0.12	0.06
rs4666451	G/G	405	26.9	27.4
	A/G	531	27.2	26.7
	A/A	184	25.7	25.8
p value d			0.43	0.13
rs2107425	G/G	572	27.5	27.5
	G/A	440	25.8	25.8
	A/A	108	26.7	26.3
p value d			0.39	0.24
rs981782	A/A	336	27.9	27.0
	A/C	544	26.5	26.9
	C/C	231	26.7	26.8
p value d			0.15	0.40
rs8051542	G/G	307	26.8	26.8
	G/A	383	25.7	25.6
	A/A	173	29.3	29.2
p value d			0.67	0.64
rs30099	C/C	929	26.9	27.0
	C/T	193	26.0	25.5
	T/T	8	28.0	24.0
p value d			0.81	0.28
rs3803662	G/G	590	26.2	26.4
	G/A	434	27.5	26.9
	A/A	90	27.1	28.6
p value d			0.53	0.37

^aAge adjusted.

^bMultivariate adjusted for the following: age (continuous), body mass index (BMI) (continuous), alcohol consumption (none, <5 g/day, 5 to 14.9 g/day, 15+ g/day), age at first birth/parity (nulliparous, age at first birth <25, age at first birth 25 to 29, age at first birth >30), history of benign breast disease (yes/no), family history of breast cancer (yes/no).

^cMultivariate adjusted for the following: age, BMI, alcohol consumption, age at first birth/parity, history of benign breast disease, family history of breast cancer, postmenopausal status/hormone use (premenopausal, never user, current user, past user).

^dp value based on genotype coded as ordinal variable regressed on square root transformed MD.