Table 4.
Frequency of molecular phenotypes among DCIS and invasive breast cancers, Nurses' Health Study (1976 to 1996)
| Immunophenotype | DCIS (n = 272) | All invasive (n = 2249) | Infiltrating ductal, NOS only (n = 1550) | p valuea | p valueb |
| n (%) | n (%) | N (%) | |||
| Luminal A | 170 (62.5) | 1650 (73.4) | 1053 (67.9) | 0.0002 | 0.08 |
| Luminal B | 36 (13.2) | 116 (5.2) | 90 (5.8) | <0.0001 | <0.0001 |
| HER2+ | 37 (13.6) | 128 (5.7) | 107 (6.9) | <0.0001 | <0.0001 |
| Basal-like | 21 (7.7) | 245 (10.9) | 223 (14.4) | 0.15 | 0.005 |
| Unclassified | 8 (2.9) | 110 (4.9) | 77 (5.0) | 0.15 | 0.14 |
ap value from Chi-Squared test comparing DCIS to all invasive tumours. bp value from Chi-Squared test comparing DCIS to infiltrating ductal tumours. DCIS, ductal carcinoma in situ.