Table 5.
Frequency of molecular phenotypes among DCIS and invasive breast cancers according to tumour gradea, Nurses' Health Study (1976 to 1996)
| Tumour type | Luminal A | Luminal B | Her2 type | Basal | Unclassified |
| DCIS | |||||
| DCIS, low nuclear grade | 26 (92.9) | 1 (3.6) | 0 | 1 (3.6) | 0 |
| DCIS, intermediate grade | 109 (79.0) | 15 (10.9) | 6 (4.4) | 6 (4.4) | 2 (1.5) |
| DCIS, high nuclear grade | 35 (33.0) | 20 (18.9) | 31 (29.3) | 14 (13.2) | 6 (5.7) |
| Invasive tumours | |||||
| Well-differentiated | 134 (95.7) | 2 (1.4) | 0 | 2 (1.4) | 2 (1.4) |
| Moderately differentiated | 344 (79.3) | 24 (5.5) | 21 (4.8) | 31 (7.1) | 14 (3.2) |
| Poorly differentiated | 252 (56.8) | 20 (4.5) | 43 (9.7) | 99 (22.3) | 30(6.8) |
aGrade of DCIS and invasive tumours as determined by centralised pathology review. DCIS, ductal carcinoma in situ.