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. 2008 Aug 4;12(4):R99. doi: 10.1186/cc6976

Table 2.

Hemodynamic variables at shock onset and during the observation period

ICU admissiona Baseline 6 hours 12 hours 24 hours 48 hours 72 hours 96 hours P value
Patients, number 40 40 40 39 37 37 35 33
Heart rate, bpm 110 ± 19 101 ± 18 84 ± 17b 84 ± 14b 84 ± 13b 83 ± 13b 79 ± 13b 78 ± 14b <0.001c
MAP, mm Hg 59 ± 19 85 ± 23 82 ± 15 85 ± 18 87 ± 15 90 ± 20 91 ± 20 90 ± 21 0.16
CVP, mm Hg 14 ± 4 12 ± 3 12 ± 4 12 ± 3 11 ± 3 11 ± 3b 10 ± 3b 9 ± 3b <0.001c
Cardiac index, L/minute per m2 1.9 ± 0.6 3.1 ± 1.1 3.2 ± 1.0 3.3 ± 0.9 3.4 ± 0.9 3.4 ± 1.0 3.5 ± 1.0 3.5. ± 0.8 0.56
SVI, mL/beat per m2 18 ± 7 32 ± 12 40 ± 14 40 ± 12 42 ± 12b 42 ± 13b 42 ± 10b 44 ± 9b 0.002c
CPI, W/m2 0.24 ± 0.14 0.61 ± 0.32 0.57 ± 0.22 0.60 ± 0.17 0.65 ± 0.18 0.68 ± 0.30 0.71 ± 0.25 0.68 ± 0.23 0.27
ScvO2, percentage 64 ± 12 71 ± 10 72 ± 6 72 ± 11 74 ± 9 77 ± 8 73 ± 11 72 ± 11 0.35
SVRI, dyne-second/cm5 per m2 2,041 ± 1,181 2,114 ± 825 1,918 ± 897 1,913 ± 777 1,895 ± 647 2,014 ± 800 2,060 ± 852 1,824 ± 569 0.78
NE, μg/kg per minute 0.12 ± 0.25 (n = 18) 0.17 ± 0.11 0.18 ± 0.11 0.18 ± 0.11 0.17 ± 0.13 0.13 ± 0.13 0.09 ± 0.08b 0.06 ± 0.07b <0.001c
AVP dosage, IU/hour NA 2.0 ± 1.6 2.2 ± 1.3 2.1 ± 1.3 2.1 ± 1.2 1.9 ± 1.3 1.3 ± 1.3 0.8 ± 1.1b <0.001c
Mil, μg/kg per minute 0.24 ± 0.19 (n = 6) 0.31 ± 0.16 0.34 ± 0.17 0.33 ± 0.16 0.30 ± 0.17 0.24 ± 0.18 0.21 ± 0.19 0.12 ± 0.13b <0.001c
Meto, mg NA 47 ± 19 NA NA 47 ± 41 52 ± 42 51 ± 42 54 ± 37 NA

aNot included in the longitudinal mixed-effects analysis. bSignificant effects versus baseline. cSignificant time effect. Data are presented as mean value ± standard deviation. AVP, arginine vasopressin; bmp, beats per minute; CPI, cardiac power index; CVP, central venous blood pressure; ICU, intensive care unit; MAP, mean arterial blood pressure; Meto, metoprolol dosage; Mil, milrinone requirements (n in parentheses indicates the number of patients who received milrinone already at intensive care unit admission); NA, not administered; NE, norepinephrine requirements (n in parentheses indicates the number of patients who received norepinephrine already at intensive care unit admission); ScvO2, central venous oxygen saturation; SVI, stroke volume index; SVRI, systemic vascular resistance index.