Table 3.
Baseline | 6 hours | 12 hours | 24 hours | 48 hours | 72 hours | 96 hours | P value | |
Patients, number | 40 | 40 | 39 | 37 | 37 | 35 | 33 | |
pH | 7.36 ± 0.09 | 7.37 ± 0.06 | 7.37 ± 0.1 | 7.38 ± 0.08 | 7.38 ± 0.07a | 7.4 ± 0.06a | 7.42 ± 0.07a | <0.001b |
Lactate, mg/dL | 22 ± 15 | 24 ± 14 | 29 ± 32 | 14 ± 10a | 12 ± 8a | 11 ± 7a | 10 ± 5a | <0.001b |
Creatinine, mg/dL | 2.3 ± 1.3 | NM | NM | 2.0 ± 1.0 | 1.8 ± 0.7 | 1.7 ± 0.8 | 1.6 ± 0.7a | 0.02b |
ASAT, IU/L | 230 ± 651 | NM | NM | 143 ± 253 | 166 ± 320 | 199 ± 474 | 153 ± 336 | 0.97 |
ALAT, IU/L | 128 ± 435 | NM | NM | 78 ± 222 | 90 ± 225 | 101 ± 207 | 90 ± 157 | 0.78 |
Bilirubin, mg/dL | 1.7 ± 1.4 | NM | NM | 1.6 ± 1.3 | 1.5 ± 1.1 | 1.5 ± 1.5 | 1.6 ± 2.2 | 0.60 |
C-reactive protein, mg/dL | 17.6 ± 8.7 | NM | NM | 17.8 ± 9.1 | 15.2 ± 9.3 | 11.6 ± 8.6 | 10 ± 8.2 | 0.001b |
Troponin I, μg/L | 8 ± 40 | NM | NM | 6 ± 21 | 3 ± 9 | 3 ± 7 | 2 ± 5 | 0.60 |
Platelet count, 109/L | 145 ± 78 | NM | NM | 132 ± 88 | 130 ± 106 | 134 ± 112 | 133 ± 123 | 0.95 |
PaO2/FiO2 | 244 ± 129 | NM | NM | 243 ± 92 | 252 ± 102 | 238 ± 84 | 262 ± 89 | 0.87 |
aSignificant effects versus baseline. bSignificant time effect. Data are presented as mean value ± standard deviation. ALAT, alanine aminotransferase; ASAT, aspartate aminotransferase; FiO2, inspiratory oxygen tension; NM, not measured; PaO2, arterial oxygen tension.