Table 2.

Hemodynamics in the treatment model

	Systolic blood pressure		Heart rate
Group	Baseline	4 hours	Baseline	4 hours
Control	125 ± 6	88 ± 6	425 ± 25	327 ± 9
LPS alone	98 ± 8	70 ± 5	465 ± 11	438 ± 28*
LPS + 0.025% of 1,600 kDa HMW HA	125 ± 5	72 ± 8	442 ± 21	448 ± 9*
LPS + 0.5% of 1,600 kDa HMW HA	112 ± 9	86 ± 6	475 ± 17	445 ± 10*
LPS + 0.1% of 1,600 kDa HMW HA	97 ± 16	87 ± 6	495 ± 18	401 ± 23*
LPS + 0.1% sodium carboxymethyl cellulose	97 ± 8	85 ± 7	464 ± 18	474 ± 30* †

There were no statistical differences between groups for systolic blood pressure. In the lipopolysaccharide (LPS)-exposed groups the heart rate was statistically higher, but there were no statistical differences between the high-molecular-weight hyaluronan (HMW HA) treatment groups. LPS + 0.1% sodium carboxymethyl cellulose was statistically higher than LPS + 0.1% HMW HA. *P < 0.01 versus control. ^†P < 0.01 versus LPS + 0.1% HMW HA.