Table 1.
Histological findings of knee joints in the meniscectomized rabbit osteoarthritis model
| Histological findings of synoviuma | Meniscectomy group (n = 6) | Sham group (n = 4) | Normal group (n = 4) | ||||||||||||
| 0 | 1+ | 2+ | 3+ | 4+ | 0 | 1+ | 2+ | 3+ | 4+ | 0 | 1+ | 2+ | 3+ | 4+ | |
| H&E staining | |||||||||||||||
| Hyperplasia of synovial cell | 0 | 0 | 5 | 1 | 0 | 1 | 0 | 3 | 0 | 0 | 4 | 0 | 0 | 0 | 0 |
| Fibrosis in connective tissue | 0 | 0 | 1 | 5 | 0 | 0 | 0 | 1 | 3 | 0 | 4 | 0 | 0 | 0 | 0 |
| Inflammatory cell infiltration in connective tissue | 4 | 0 | 1 | 1 | 0 | 4 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 |
| KM1334 immunohistochemistryb | |||||||||||||||
| Positive reactions in synovial cells | 0 | 6 | 0 | 0 | 0 | 1 | 3 | 0 | 0 | 0 | 3c | 1 | 0 | 0 | 0 |
| Positive reactions in fibroblastic cells | 0 | 5 | 1 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 |
| Positive reactions in cartilage | 6c | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 4c | 0 | 0 | 0 | 0 |
| Cartilage degeneration scorec (mean ± standard error) | 6.0 ± 0.8 | 0.5 ± 0.5 | 0.0 ± 0.0 | ||||||||||||
aHistological findings criteria: 0, non remarkable; 1+, very slight; 2+, slight, 3+, moderate; 4+, marked. bKM1334; an anti-FGF8 antibody. cSafranin O/fast green staining sample examined using the modified Mankin scale.