Table 7.
KEGG pathways/complexes significantly affected by intra-group inter-individual gene expression variance in osteoarthritis (OA) compared with rheumatoid arthritis (that is, higher variances in OA)
| KEGG identification number | Pathway/complex | B (E) | χ2 | P value | Affected genes | |
| 1 | hsa00190 | Oxidative phosphorylationa | 10 (1) | 75.6 | <0.01 | COX5B, NDUFA6, NDUFA8, NDUFB2, NDUFB4, SDHC, NDUFB6, aNDUFC1, NDUFA13, ATP5G3 |
| 2 | hsa04010 | MAPK signaling pathwaya | 5 (2) | 3.8 | 0.17 | DUSP5, RASGRP3, FAS, MAPK11, TAOK1 |
| 2a | hsa04010 | MAPK signaling pathwaya (JNK/p38 MAPK sub-pathway) | 4 (1) | 6.54 | 0.03 | DUSP5, FAS, MAPK11, TAOK1 |
| 3 | hsa00790 | Folate biosynthesisa | 3 (0) | 22.03 | <0.01 | ASCC3, SETX, SMARCA5 |
| 4 | hsa00500 | Starch and sucrose metabolisma | 3 (1) | 7.86 | 0.01 | ASCC3, SETX, SMARCA5 |
aSpecifically affected in rheumatoid arthritis. B, absolute frequency; E, expected frequency; JNK, c-jun kinase; KEGG, Kyoto Encyclopedia of Genes and Genomes; MAPK, mitogen-activated protein kinase.