Table 2.

BOKS analysis: independent association of standardized biomarkers with BML (BML > 0) per SD of change in marker

			Univariate association			Full model (including age, sex and BMI)
Marker	(BML = 0)	(BML > 0)	OR	95% CI	R2	Full model R2	Full model ROC area
Ln-BSAP	3.48 (0.35)	3.57 (0.36)	1.4	(0. 9, 2.0)	2.58	14.56	0.701
Ln-osteocalcin	2.73 (0.51)	2.80 (0.55)	1.2	(0.8, 1.7)	0.8	13.41	0.687
Ln-NTx	-3.47 (1.07)	-3.27 (0.78)	1.4	(1.0, 2.0)	3.05	14.55	0.697

BMI, body mass index; BML, bone marrow; BOKS, Boston Osteoarthritis Knee Study; BSAP, bone-specific alkaline phosphatase; Ln, Natural Log; NTx, type I collagen N-telopeptide; SD, standard deviation.