Table 4.

Framingham analysis: independent association of standardized biomarkers with BML (BML > 0) per SD of change in marker

Marker	Adjusted for age, sex, and BMI	Multi-adjusted (adjusted for age, sex, BMI, and BMD)	Multi-adjusted (Adjusted for OA, age, sex, BMI, and BMD)
Ln-BSAP	1.4 (0.9 to 2.1)	1.4 (0.9 to 2.0)	1.26 (0.75 to 2.11)
Ln-osteocalcin	1.1 (0.7 to 1.7)	1.1 (0.7 to 1.7)	1.60 (0.99 to 2.57)
Ln-NTx	1.7 (1.1 to 2.7)	1.7 (1.1 to 2.6)	1.65 (0.96 to 2.83)

Values are presented as odds ratio (95% confidence interval). BML, bone marrow; BSAP, bone-specific alkaline phosphatase; Ln, Natural Log; NTx, type I collagen N-telopeptide; SD, standard deviation.