Figure 6. In vivo therapeutic effect of the T-cell clones.
C57BL/KaLwRij mice (5 per group) were challenged intravenously with 2 × 106 5TGM1 myeloma cells, and one week later, 2 × 106 T-cell clones were adoptively transferred into tumor-bearing mice by an intravenous injection. PBS and splenocytes from naïve mice served as controls. Serum samples were collected weekly and tumor burden was monitored by measuring circulating IgG2b Id protein. A, concentrations of serum IgG2b Id protein in mice receiving PBS or different T cells as indicated. B, survival data of mice receiving PBS or different T cells. Arrows indicate injection of T cells. Representative results of one out of two performed are shown.