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. Author manuscript; available in PMC: 2008 Oct 29.
Published in final edited form as: Thromb Haemost. 2008 Oct;100(4):678–684. doi: 10.1160/th08-02-0118

Table 3. Clinical Outcomes.

Results are presented according to clinical laboratory testing status (Confirm+ or Confirm-) and according to clinical diagnosis of HIT (HIT+, HIT?, and HIT-). Abbreviations: HIT, heparin-induced thrombocytopenia; HITT, heparin-induced thrombocytopenia with thrombosis; DTI, direct thrombin inhibitor.

Outcome Confirm+ (n=98) Confirm- (n=17)
HIT+
(n=56)
HIT?
(n=15)
HIT-
(n=27)
HIT+/HIT?
(n=3)
HIT-
(n=14)
Thromboembolic event (HITT; n=32) 26 (46%) 6 (40%) 0 0 0
Treated with a DTI (n=50) 41/56 (73%) 4/15 (27%) 1/27 (4%) 3/3 (100%) 1/14 (7%)
 Isolated HIT patients 18/30 (60%) 0 - 3/3 (100%) 0
 HIT with thrombosis patients 23/26 (88%) 4/6 (67%) - 0 0
 Hemorrhagic complication * 11/41 (27%) 2/4 (50%) 0 1/3 (33%) 0
 Thromboembolic event * 3/41 (7%) 0 1/27 (4%) 2/3 (66%) 1/14 (7%)
 Death * 9/41 (22%) 2/4 (50%) 1/27 (4%) 1 (33%) 0
Not treated with a DTI (n=65) 15/56 (27%) 11/15 (73%) 26/27 (96%) 0 13/14 (93%)
 Hemorrhagic complications 2/15 (13%) 1/11 (9%) 8/26 (31%) - 3/14 (21%)
 Thromboembolic complications 2/15 (13%) 2/11 (18%) 4/26 (15%) - 7/14 (50%)
 Death 3/15 (20%) 2/11 (18%) 4/26 (15%) - 2/14 (14%)
*

Clinical events occurring after diagnosis of HIT initially made. These events may have occurred while the patient was on a DTI, or after the DTI had been discontinued.