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. Author manuscript; available in PMC: 2008 Oct 29.
Published in final edited form as: Front Biosci. 2008 May 1;13:3869–3883. doi: 10.2741/2975

Figure 3.

Figure 3

hnRNP H promotes U11 binding to the NRS. A) The sequence of the U11 binding site (boxed green) and the downstream G-rich region (underlined) is shown above a schematic of the NRS. The NRS, shown in red, is depicted with SR proteins promoting U1 binding (arrow). The G-rich region (hatched pink) binds hnRNP H (yellow H) that in turn promotes U11 binding (arrows). The interaction might direct or through another protein (?). B) The observation that hnRNP H promotes U11 binding to the NRS led to the finding that a subset of U12-dependent cellular introns harbor G tracts requires hnRNP H for U11 binding (arrow) and splicing.