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. Author manuscript; available in PMC: 2008 Oct 29.
Published in final edited form as: Front Biosci. 2008 May 1;13:3869–3883. doi: 10.2741/2975

Figure 4.

Figure 4

Polyadenylation pathway and factors. A) Poly(A) addition occurs by endonucleolytic cleavage of the RNA between the AAUAAA and GU-rich elements at the eventual poly(A) addition site (black triangle), and subsequent addition of the poly(A) tail to the 5′ cleavage product. The downstream fragment is degraded. B) Schematic of polyadenylation factors. The multi-subunit CPSF (blue, molecular size of subunits indicated) is shown interacting with the AAUAAA signal, as are components of CstF (orange) bound to the GU-rich element. CFIm assists in CPSF binding via hFip. PAP, and CFIIm are also shown.