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. Author manuscript; available in PMC: 2009 Sep 1.
Published in final edited form as: Cytokine. 2008 Aug 13;43(3):350–358. doi: 10.1016/j.cyto.2008.07.011

Figure 1.

Figure 1

RLR signaling pathway and its negative regulatory molecules. Positive signals and molecules are indicated as black arrows and black letters, respectively. Negative signals and negative regulators are indicated as red lines and red letters. For references, see text. Abbreviations; NSV: Negative stranded virus; PSV: Positive stranded virus; RIG-I: retinoic acid inducible gene-I; MDA5: melanoma differentiated-associated gene-5; LGP2: laboratory of genetics and physiology-2; RNF125: ring-finger protein 125: TRIM25: tripartite motif 25; SIKE: Suppressor of IKKε; DAK: Dihydroxyacetone kinase; FADD: Fas-Associated protein with Death Domain; DUBA: Deubiquitinating enzyme A; TRAF: tumor necrosis factor receptor-associated factor; Ub: Ubiquitin; CYLD: cylindromatosis; ATG: Autophagy-related gene; NLR: nucleotide-binding domain and leucine-rich repeat.