Table 2.
Cellular adiponectin and response to pioglitazone
|
SAT Culture |
VAT Culture | |||
|---|---|---|---|---|
| Pio | 0 μM | 10 μM | 0 μM | 10 μM |
| ND | 164.3±50.5 | 318.5±51.9* | 281.3±38.7 | 491.3±69.2* |
| T2D | 209.1±63.7 | 411.3±109.7* | 107.4±13.4 | 128.5±14.7 |
Results are means ± SE in %; n = 11 for ND SAT and VAT, n = 8 for T2D SAT, and n = 6 for T2D VAT. Cellular adiponectin content in ND adipose tissue (AT) and type 2 diabetic (T2D) AT and treatment effect of pioglitazone (Pio). Explants were cultured for 7 days in defined medium ±10 μM Pio. Fat cell protein extracts were prepared from fresh and cultured ND and T2D subcutaneous (S)AT and visceral (V)AT. Adiponectin expression is presented as a percentage of the value determined in fresh adipocytes from the same individual.
*
P < 0.05 vs. paired untreated control.