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Liver and fat weights in lean and high-fat diet (HFD)-fed mice after estradiol (E2) treatment. A: liver weights. Data are presented as means ± SE; n = 5–6 mice. B: abdominal fat weights. Data are presented as means ± SE; n = 5–6. ***P < 0.001 for lean and lean + E2 vs. HFD mice. **P < 0.01 for HFD vs. HFD + E2 mice.
