Fig. 4.

Plasma levels and white adipose tissue (WAT) expression of leptin, resistin, and adiponectin after E₂ treatment. A: plasma leptin concentrations. Data are presented as means ± SE; n = 5–6. ***P < 0.001 for lean and lean + E₂ vs. HFD mice. **P < 0.001 for HFD vs. HFD + E₂ mice. B: plasma resistin concentrations. Data are presented as means ± SE; n = 5–6. ***P < 0.001 for lean and lean + E₂ vs. HFD mice and for HFD vs. HFD + E₂ mice. C: plasma adiponectin levels. Data are presented as means ± SE; n = 5–6. *P < 0.05 for lean vs. lean + E₂ mice. ***P < 0.001 for HFD vs. HFD + E₂. D: leptin, resistin, and adiponectin mRNA levels in WAT. Data are presented as means ± SE; n = 6. *P < 0.05 and **P < 0.01 vs. vehicle-treated HFD mice.