Fig. 5.

Effects of TNBS on mechanoreceptor stimulus-response curves evoked by von Frey hairs. Stimulus-response curves to a range of von Frey hairs (0.1–1.1 mN) applied to identified mechanoreceptor transduction sites in the rectum were largely unchanged by TNBS treatment at either 6 or 30 days posttreatment (A and B). However, small but consistent differences were seen in the thresholds of units at 6 days but not 30 days. In C and D, the numbers of units (n) responding to a 0.1 mN von Frey hair is shown for TNBS-treated and saline-treated animals at 6 days and 30 days, respectively (*P < 0.05).