Fig. 5.

Npc1l1^−/− and ezetimibe-treated mice are protected from diet-induced loss of insulin sensitivity. A: control and Npc1l1^−/− mice were subjected to an insulin tolerance test after 6 wk of Western diet. After baseline glucose was measured, animals were given insulin (0.75 U/kg) by intraperitoneal injection and glucose was monitored for 2 h thereafter (n = 8–10 per group). Groups were significantly different, *P < 0.01, at all times after time 0. B: insulin sensitivity was similarly measured in different groups of mice fed Western diet with or without ezetimibe for 3 wk (n = 8 per group). Groups were significantly different, *P < 0.02, at 15 and 30 min.