Table 1.
Significant overrepresentation of Gene Ontology terms among differentially expressed genes in Study 1
| Pathway | GO Accession No. | All Genes | Observed | Expected | Bonferroni Corrected P Value |
|---|---|---|---|---|---|
| Steroid biosynthesis | 0006694 | 22 | 8 | 0.76 | 0.000161 |
| Lipid biosynthesis | 0008610 | 65 | 12 | 2.25 | 0.000679 |
| Sterol biosynthesis | 0016126 | 14 | 6 | 0.48 | 0.00168 |
| Lipid metabolism | 0006629 | 164 | 18 | 5.67 | 0.00429 |
| Sterol metabolism | 0016125 | 25 | 7 | 0.86 | 0.00662 |
| Cholesterol biosynthesis | 0006695 | 11 | 5 | 0.38 | 0.00825 |
| Steroid metabolism | 0008202 | 38 | 8 | 1.31 | 0.0155 |
| Isoprenoid biosynthesis | 0008299 | 3 | 3 | 0.10 | 0.0187 |
| Cholesterol metabolism | 0008203 | 21 | 6 | 0.73 | 0.0248 |
| Cellular lipid metabolism | 0044255 | 140 | 15 | 4.84 | 0.0339 |
| Alcohol metabolism | 0006066 | 81 | 11 | 2.80 | 0.0391 |
Column ‘All Genes’ refers to genes on the array annotated with the particular Gene Ontology (GO) term.