Figure 4.

RME-2 is a member of the LDLR superfamily of lipoprotein receptors (GenBank accession number AF185706). Repetitive motifs shown include acidic ligand-binding sequences with six cysteines each, EGF-like repeats with six cysteines each (B.1 and B.2 type; Herz et al., 1988), YWTD repeats, which are thought to form a β-propeller structure (Springer, 1998), and the consensus internalization signal FDNPXY. VLDLR/OVR, very low-density lipoprotein receptor (Gafvels et al., 1993)/chicken yolk receptor (Shen et al., 1993); Dm Yolkless, Drosophila yolk receptor (Schonbaum et al., 1995); Ce LRP-1/Megalin, C. elegans megalin gene product (Yochem and Greenwald, 1993). Only a partial map of lrp-1 motifs is shown because of its large size. For a complete description, see Yochem and Greenwald (1993).