Table 1.
Characteristics of the study participants used in the meta-analysis
| Cohort | n (Male/Female) | Age, yr | BMI, kg/m2 | SBP, mmHg | DBP, mmHg | Genotype Frequency (n) | Genotype Proportion, % | MAF, % |
|---|---|---|---|---|---|---|---|---|
| Danish whites | ||||||||
| Study 1 (Ref. 8)*† | 459/554 | 57.23 (7.08) | 25.9 (3.98) | 133.12 (17.98) | 84.07 (10.86) | 454/442/117 | 44.8/43.6/11.6 | 33.4 |
| Study 3 (Ref. 8)*† | 75/82 | 65.87 (5.12) | 25.22 (3.82) | 134.75 (19.09) | 77.65 (11.23) | 63/69/25 | 40.1/44.0/15.9 | 37.9 |
| Study 4 (Ref. 8)*† | 430/268 | 59.3 (9.65) | 29.3 (5.04) | 158.28 (23.38) | 95.14 (13.93) | 281/316/101 | 40.2/45.3/14.5 | 37.1 |
| Study 5 (Ref. 8)*† | 256/216 | 46.53 (12.38) | 24.26 (3.08) | 134.44 (19.12) | 76.57 (9.81) | 212/195/65 | 44.9/41.3/13.8 | 34.4 |
| UK whites | ||||||||
| MRC Ely† | 285/409 | 54.55 (10.3) | 26.41 (4.06) | 126.65 (16.59) | 76.41 (10.83) | 269/341/84 | 38.8/49.1/12.1 | 36.7 |
| CCCS cases† | 328/186 | 63.56 (7.82) | 29.71 (5.22) | 144.49 (17.05) | 86.53 (10.67) | 230/226/58 | 44.7/44/11.3 | 33.3 |
| CCCS controls† | 324/183 | 63.85 (7.83) | 27.27 (4.14) | 138.41 (17.68) | 84.93 (11.23) | 211/215/81 | 41.6/42.4/16 | 37.2 |
| Pima Indians† | 495/593 | 20.73 (13.9) | 25.66 (8.21) | 116.26 (20.4) | 68.16 (14.53) | 735/318/35 | 67.6/29.2/3.2 | 17.8 |
| French Canadians (Ref. 2)† | 77/189 | 42.4 (10.15) | 52.83 (9.98) | 142.66 (18.71) | 86.13 (11.87) | 105/122/39 | 39.5/45.9/14.6 | 37.6 |
| EPIC | ||||||||
| Obese† | 484/627 | 59.43 (8.77) | 32.90 (2.87) | 140.93 (17.3) | 86.45 (11.25) | 480/492/139 | 43.2/44.3/12.5 | 34.7 |
| Cohort† | 995/1,133 | 58.96 (8.94) | 26.57 (4.01) | 135.76 (17.56) | 82.73 (10.8) | 932/960/236 | 43.8/45.1/11.1 | 33.6 |
| Asian Indians | ||||||||
| Cases (Ref. 3)‡ | 238/329 | 50.0 (12.0) | 25.1 (4.2) | 128.0 (18.0) | 77.0 (11.0) | 303/212/52 | 53.4/37.4/9.2 | 27.9 |
| Control (Ref. 3)‡ | 399/576 | 44.0 (13.0) | 23.2 (4.4) | 120.0 (17.0) | 75.0 (10.0) | 534/360/81 | 54.8/36.9/8.3 | 26.8 |
| Danish whites (Ref. 4)‡ | 1,108/1,147 | 24.48 (4.27) | 931/1036/288 | 41.3/45.9/12.8 | 35.7 |
Values are unadjusted means (SD); n = 12,455 subjects. An additional 1,504 individuals, in whom quantitative trait data for blood pressure and body mass index (BMI) were collected, were also included in the hypertension meta-analysis. SBP, systolic blood pressure; DBP, diastolic blood pressure; MAF, minor allele frequency; CCCS, Cambridgeshire Type 2 diabetes Case-Control Study; MRC, Medical Research Council; EPIC, European Prospective Investigation of Cancer.
*
Studies 1, 3, 4, and 5 correspond to the study numbers mentioned in the paper.
†
Studies with raw data.
‡
Studies from published paper. Mean, SD, and ANOVA P values were obtained from published papers or from authors.