Table 3.
Meta-analysis results for DBP stratified by PPARGC1A Gly482Ser genotypes
| Cohort | DBP, mmHg |
ANOVA, P Value | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genotype Frequencies |
Gly/Gly | Gly/Ser | Ser/Ser | Significance of Interaction | |||||||||
| Gly/Gly | Gly/Ser | Ser/Ser | Mean | 95% CI | Mean | 95% CI | Mean | 95% CI | Gene-Sex | Gene-Age | Gene-BMI | ||
| Danish whites | |||||||||||||
| Study 1 (Ref. 8)*† | 454 | 442 | 117 | 84.4 | 83.4–85.4 | 84.1 | 83.1–85.1 | 83.0 | 81.1–84.9 | 0.467 | 0.575 | 0.759 | 0.359 |
| Study 3 (Ref. 8)*† | 63 | 69 | 25 | 78.7 | 75.9–81.5 | 76.8 | 74.1–79.5 | 77.4 | 73.0–81.8 | 0.601 | 0.053 | 0.659 | 0.776 |
| Study 4 (Ref. 8)*† | 281 | 316 | 101 | 95.3 | 93.7–96.9 | 95.7 | 94.2–97.2 | 92.7 | 90.0–95.4 | 0.159 | 0.613 | 0.711 | 0.279 |
| Study 5 (Ref. 8)*† | 212 | 195 | 65 | 76.7 | 75.4–78 | 75.7 | 74.4–77.0 | 78.7 | 76.4–81.0 | 0.080 | 0.463 | 0.971 | 0.467 |
| Pima Indians† | 735 | 318 | 35 | 67.9 | 67.1–68.7 | 68.5 | 67.2–69.8 | 70.5 | 66.6–74.4 | 0.363 | 0.924 | 0.593 | 0.504 |
| UK whites | |||||||||||||
| MRC Ely† | 233 | 306 | 73 | 77.0 | 75.7–78.3 | 75.9 | 74.8–77.0 | 73.2 | 70.9–75.5 | 0.018 | 0.251 | 0.532 | 0.397 |
| CCCS cases† | 175 | 176 | 43 | 86.3 | 84.8–87.8 | 85.1 | 83.6–86.6 | 85.8 | 82.7–88.9 | 0.541 | 0.236 | 0.214 | 0.327 |
| CCCS controls† | 194 | 197 | 75 | 83.9 | 82.4–85.4 | 84.6 | 83.0–86.2 | 87.0 | 84.5–89.5 | 0.131 | 0.113 | 0.266 | 0.593 |
| French Canadians (Ref. 2)† | 64 | 73 | 19 | 84.6 | 82.1–87.1 | 87.5 | 85.2–89.8 | 89.0 | 84.4–93.6 | 0.137 | 0.085 | 0.4 | 0.19 |
| EPIC | |||||||||||||
| Obese† | 364 | 339 | 96 | 86.3 | 85.2–87.4 | 86.1 | 85.0–87.2 | 86.0 | 83.9–88.1 | 0.973 | 0.051 | 0.188 | 0.854 |
| Cohort† | 762 | 789 | 201 | 81.9 | 81.2–82.6 | 82.0 | 81.3–82.7 | 82.5 | 81.1–83.9 | 0.805 | 0.878 | 0.59 | 0.858 |
| Danish whites (Ref. 4)‡ | 931 | 1,036 | 288 | 81.8 | 81.1–82.5 | 82.3 | 81.7–82.9 | 82.0 | 80.7–83.3 | 0.39 | |||
| Asian Indians | |||||||||||||
| Controls (Ref. 3)‡ | 534 | 360 | 81 | 76.0 | 75.2–76.8 | 75.0 | 74.0–76.0 | 75.0 | 72.8–77.2 | 0.6 | |||
| Cases (Ref. 3)‡ | 303 | 212 | 52 | 79.0 | 77.8–80.2 | 77.0 | 75.5–78.5 | 75.0 | 72.3–77.7 | 0.007 | |||
| Slovenian whites | |||||||||||||
| Cases (Ref. 5)‡ | 114 | 118 | 29 | 84.7 | 83–86.4 | 85.7 | 83.8–87.6 | 85.0 | 82.5–87.5 | 0.74 | |||
| Controls (Ref. 5)‡ | 14 | 15 | 1 | 83.8 | 78.1–89.5 | 84.8 | 78.5–91.1 | 84.0 | 0.7 | ||||
| Overall | 5,433 | 4,961 | 1,301 | 80.3 | 80–80.6 | 81.5 | 81.2–81.8 | 82.1 | 81.5–82.7 | 0.651§ | 0.715 | 0.00004 | 0.953 |
| Standard error | 0.005§ | ||||||||||||
| Cohort heterogeneity P | 0.021§ | ||||||||||||
| Ethnicity heterogeneity P | 0.414§ | ||||||||||||
| Caucasian only | |||||||||||||
| Overall | 3,861 | 4,071 | 1,133 | 83.4 | 83.0–83.7 | 83.3 | 83.0–83.7 | 83.3 | 82.7–83.9 | 0.659§ | 0.700 | 0.789 | 0.348 |
| Heterogeneity P | 0.109§ | ||||||||||||
*
Studies 1, 3, 4, and 5 correspond to the study numbers mentioned in the paper.
†
Studies with raw data. The main effect and interaction analyses are adjusted for age and sex.
‡
Studies from published paper. Mean, SD, and ANOVA P values were obtained from published papers or from authors.
§
Based on 10,000 simulations. A random-effect generalized linear model is applied if P < 0.05 for heterogeneity; otherwise, a fixed model is applied.